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201712/19

What is CSTD?

According to NIOSH and ISOPP

A closed system drug transfer device or "CSTD" is a drug transfer device that mechanically prohibits the transfer of environmental contaminants into a system and the escape of hazardous drug or vapor concentrations outside the system.

NIOSH

A closed system is a device that does not exchange unfiltered air or contaminants with the adjacent environment. This closed system definition originally referred to a biological safety cabinet and not to the drug containment devices. A drug containment device is one that is both airtight and leakproof.
A closed system drug transfer device is a drug transfer device that mechanically prohibits the transfer of environmental contaminants into the system and the escape of hazardous drug or vapor concentrations outside the system.

Ref:
National Institute for Occupational Safety and Health (September 2004). "Preventing Occupational Exposure to Antineoplastic and Other Hazardous Drugs in Health Care Settings". Centers for Disease Control and Prevention. Retrieved October 26, 2009.
ISOPP Journal of Oncology Pharmacy Practice Volume 13, 2007, pg 28-29.

ISOPP

The first defines ‘closed’ in terms of microbiological contamination. This definition deals purely with introducing micro-organisms into a sterile product, and there is no consideration of the sterile product coming out of the vial contaminating the environment.
The second category defines ‘closed’ in relation to chemical contamination and refers to drug transfer devices that mechanically prohibit the transfer of environment contaminants into the system and the escape of hazardous drug or vapour concentrations outside the system. ISOPP, however, agree that the NIOSH definition is the most comprehensive and complete.

Ref:
ISOPP Journal of Oncology Pharmacy Practice Volume 13, 2007, pg 28-29.

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